Premium
Glutathione concentration and glutathione peroxidase activity are associated with the risk of liver cirrhosis independently of oxidative stress
Author(s) -
Huang YiChia,
Cheng ShaoBin,
Liu HsiaoTien,
Lai ChiaYu
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.801.1
Subject(s) - cirrhosis , oxidative stress , glutathione , glutathione peroxidase , medicine , antioxidant , endocrinology , odds ratio , chemistry , biochemistry , catalase , enzyme
Oxidative stress has been observed to be associated with the risk of liver cirrhosis. Glutathione is synthesized in the liver, with its dependent antioxidant enzymes play important roles in antioxidant defense system. However, the relationship between oxidative stress and the glutathione antioxidant system to mediate the risk of liver cirrhosis has not been clearly determined. We investigated whether the glutathione antioxidant system is dependent or independent of oxidative stress linked with the risks for liver cirrhosis. This was a case control study. Sixty‐eight patients with liver cirrhosis (case) and 110 healthy subjects (control) were recruited. Patients with liver cirrhosis had significantly lower glutathione concentrations and higher glutathione peroxidase (GPx) activity than healthy subjects. There was no significant difference in oxidative stress status between groups. Plasma glutathione is significantly correlated with GPx activity ( r = −0.22, p < 0.05) and oxidative stress indicator ( r = 0.31, p < 0.01) in all subjects. Subjects with higher plasma glutathione concentration exhibited significantly decreased risk of liver cirrhosis (odds ratio, 0.95; p = 0.01), while subjects with lower plasma GPx activity significantly increased the risk of liver cirrhosis (odds ratio, 1.03; p < 0.01) with adjustment for potential confounders. Glutathione and GPx activity plays a significant role in the risk of liver cirrhosis. Support or Funding Information This study was supported by the Ministry of Science and Technology, Taiwan (MOST 104‐2320‐B‐040‐009‐MY3).