Premium
Effects of Low Calorie Sweetener D‐psicose on Lipid Metabolism in Rats
Author(s) -
Chen Jingjing,
Huang Weilai,
Jiang Bo
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.798.1
Subject(s) - lipid metabolism , lipogenesis , fatty acid synthase , endocrinology , adipose tissue , medicine , hormone sensitive lipase , chemistry , perilipin , adiponectin , fatty acid synthesis , metabolism , hepatic lipase , biochemistry , lipoprotein lipase , biology , fatty acid , lipolysis , obesity , insulin resistance
This study aimed to investigate the effect of new generation low calorie sweetener D‐psicose on body weight management and lipid metabolism of rats compared with other traditional dietary carbohydrates. Five groups of Wistar rats were administrated with diets containing 5% of glucose, fructose, cellulose and D‐psicose for 4 weeks, respectively. After sacrifice, blood lipid profile, tissue morphology and related genes participated in lipid metabolism were examined. Our results indicated rats supplemented with D‐psicose had minimum body weight gain, less epididymal fat and smaller adipose cell size. The blood lipid profile and antioxidant level of rats fed with D‐psicose was improved. D‐psicose was shown to regulate lipid metabolism by increasing lipid metabolism related enzymes such as succinated dehydrogenase in serum and liver, as well as hepatic lipase. D‐psicose could prevent fat accumulation by suppressing the expression of lipogenesis related genes including ACCα (Acetyl‐CoA carboxylase), FAS (fatty acid synthase) and SREBP‐1c (sterol regulatory element binding proteins), while stimulating the expression of fatty acid oxidation related genes including AMPKα2 (AMP‐activated protein kinase), HSL (hormone sensitive lipase) and PPARa (peroxisome proliferator activated receptors). In conclusion, as a promising new generation low calorie sweetener, D‐psicose may be used to regulate lipid metabolism and prevent obesity.