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Low Manganese May Increase the Risk of Diabetes in Chinese Adults
Author(s) -
Liu Liping,
Du Shufa,
Wang Huijun,
Mendez Michelle A,
Popkin Barry M
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.797.19
Subject(s) - quartile , diabetes mellitus , medicine , body mass index , odds ratio , manganese , hemoglobin , logistic regression , confidence interval , chemistry , endocrinology , organic chemistry
Background Diabetes has rapidly increased in past two decades in China. Recent studies reported that manganese may help regulate glucose metabolism, while little is known about the relationship between manganese concentrations and the risk of diabetes. Methods We used a subsample (n=5,587 adults aged 18 – 65 years) who provided blood and toenail samples in 2009 from the China Health and Nutrition Survey, a study covering 9 provinces varying in environment and urbanization in China. We measured manganese on toenail samples with inductively coupled plasma mass spectroscopy (ICP‐MS), hemoglobin A1c (HbA1c) on fresh whole blood samples with high performance liquid chromatography, insulin on serum samples with radioimmunology method, and glucose on serum samples with Hitachi 7600 Auto‐analyzer. We estimated the association between manganese concentrations and diabetes by using logistic regression models in which we controlled for age, gender, body mass index, education, social‐economic status, residential region (urban/rural), and urbanization index. Results The median manganese concentration was 3.86 mg/kg with a range of 0 – 60.58 mg/kg. The prevalence of diabetes defined as HbA1c ≥ 6.5% was 8.15%, 6.88%, 6.20%, and 4.36% from the 1 st to 4 th quartile of manganese concentration (p trend <0.001), respectively, and the average prevalence was 6.38%. Compared to the 1 st quartile, the odds ratio of diabetes from 2 nd to 4 th quartile was 0.81 (95% CI: 0.59 – 1.11), 0.83 (95% CI: 0.60 – 1.17), and 0.58 (95% CI: 0.40 – 0.84), respectively. The average serum glucose was 95.87 mg/dL. Serum glucose decreased with increased manganese, but it was significantly lower in the 4 th quartile only, compared to the 1 st quartile (94.06 vs. 97.68 mg/dL, p trend =0.01). Conclusion Manganese is an important element for human health. Our findings suggest that low manganese may increase the risk of diabetes. Manganese may play an important role in preventing the development diabetes. Support or Funding Information This study is supported by the NIH (R01‐HD30880) and the NIH Fogarty International Center (D43 TW009077)