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Modulation of Nutrient Sensing Networks by Anti‐nutritional Factors in Fish
Author(s) -
He Gen,
Bian Fuyun,
Tian Juan,
Wang Kaidi,
Zhou Huihui
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.792.12
Subject(s) - anabolism , nutrient sensing , signal transduction , catabolism , biology , nutrient , protein kinase b , microbiology and biotechnology , fish <actinopterygii> , metabolism , cell signaling , metabolic pathway , insulin , insulin receptor , tor signaling , carbohydrate metabolism , biochemistry , endocrinology , insulin resistance , ecology , fishery
Nutrient sensing is composed of intervened signaling pathways that respond to the availability of nutrients (amino acids, glucose, lipids, etc.) and modulate metabolism. Contrast to previous efforts on the understanding of the effects of nutritional components, much less was known on the molecular responses generated by anti‐nutritional factors (ANFs), which could exert significant influence on the dietary performances and animal health. Therefore, the present study was designed to screen and characterize the influences of ANFs on the nutrient sensing networks and metabolism in fish. The dose‐responses of ANFs on target of rapamycin (TOR) signaling, integrated stress response (ISR) pathway, insulin/IGF signaling, and major metabolism pathways were characterized in both fish cell lines and animal studies. Among ANFs, gossypol and soybean saponins were found to suppress TOR and activate ISR signaling, while promote catabolism. Concanavalin A was found to cause inhibited insulin/IGF1/Akt signaling and consequently lead to apoptosis. These results should provide new explanation on the profound physiological effects of these anti‐nutritional factors. Support or Funding Information This study was supported by National Natural Science Foundation to G.H. (31572627)