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Calcium to Magnesium Intake Ratio and Prostate Cancer Aggressiveness
Author(s) -
Omofuma Omonefe,
Arab Lenore,
Su L. Joseph,
Bensen Jeannette T.,
Fontham Elizabeth T.H.,
Mohler James L.,
Steck Susan E.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.790.33
Subject(s) - prostate cancer , medicine , odds ratio , quartile , confidence interval , cancer , prostate , calcium , oncology , urology , gynecology , endocrinology
Objective Experimental studies suggest that calcium and magnesium compete for membrane binding sites. An imbalance in the level of these micronutrients has been associated with multiple chronic diseases, though few studies to date have examined the relationship with prostate cancer. The goal of this study was to examine the dietary intake ratio of calcium to magnesium and its association with prostate cancer aggressiveness in African Americans (AAs) and European Americans (EAs). Method Calcium and magnesium intakes were estimated using a food frequency questionnaire in 996 AA and 1064 EA men with a recent histologically confirmed diagnosis of prostate cancer from the North Carolina – Louisiana Prostate Cancer Project (PCaP). High aggressive disease was defined as Gleason sum ≥8, or PSA> 20ng/ml, or Gleason score ≥7 AND clinical stage T3–T4, and the comparison group was all other prostate cancer cases. Logistic regression was used to determine the adjusted odds ratio (OR) and 95% confidence intervals (95% CI) for high aggressive prostate cancer by quartile of calcium to magnesium intake ratio. Results There was a positive association for prostate cancer aggressiveness across the quartiles of calcium to magnesium intake ratio, with odds of high aggressive prostate cancer in the upper quartiles; OR Q2VS.Q1 :1.46. 95% CI: 1.02 – 2.07, OR Q3VS.Q1 :1.42. 95% CI: 1.00 – 2.03 and OR Q4VS.Q1 : 1.69, 95% CI: 1.19 – 2.40. When stratified by race, the association was observed in both AA men, OR Q4VS.Q1 : 1.72, 95% CI: 1.08–2.74 and EA men OR Q4VS.Q1 : 1.89, 95% CI: 1.12 – 3.19. Conclusion Among both African American and European American men diagnosed with prostate cancer, a higher calcium to magnesium intake ratio as reported in the year prior to diagnosis was associated with higher odds of high aggressive prostate cancer. Support or Funding Information The North Carolina‐Louisiana Prostate Cancer Project