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Korean Solar Salt Suppresses Concomitant Induction of Obesity and AOM/DSS‐Based Colon Cancer in C57BL/6 Mice
Author(s) -
Park KunYoung,
Ju Jaehyun,
Park EuiSeong,
Choi ShinIl
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.790.27
Subject(s) - azoxymethane , medicine , colorectal cancer , endocrinology , cancer
The aim of our research is to elucidate health benefits of Korean solar salt samples with different processing methods in concomitant in vivo induction of obesity and colon cancer (using azoxymethane (AOM) and dextran sodium sulfate (DSS)), using C57BL/6 mice. All mice, except for Normal group, were fed with high‐fat diet (HFD; 45% Cal from fat), with 1% salt samples in the diet (SS‐S1 for conventionally manufactured solar salt, SS‐S2 for solar salt with charcoal‐ and magnetic filtration of SS‐S1, SS‐S3 for solar salt made by concentrated new sea water, SS‐S4 for solar salt made by concentrated new sea water after charcoal‐ and magnetic filtration of SS‐S3, and nine‐time‐baked bamboo salt (BS‐9×) used as a positive control; corresponding with a human dose of 12 grams of salt/day) or not, and underwent AOM/DSS colon cancer induction. Of all the samples observed, SS‐S3 and SS‐S4 suppressed shortening of colon length, lowered colon weight‐to‐length ratio, reduced colon tumor counts. Also, SS‐S3 suppressed weight of epididymal adipose tissue (EAT), reduced serum concentration of triacylglycerol (TG), total cholesterol (TC) and leptin. SS‐S3 suppressed adipogenesis‐related mRNA expression both in liver and EAT; it promoted apoptosis‐related gene expression in colon and suppressed inflammation‐related mRNA expression in colon as well. Such efficacies were found to have improved when solar salt was baked into BS‐9×. Taken together, solar salt, when carefully processed, may improve health benefit against obesity and cancer. Support or Funding Information This work was supported by a grant 20130290 to Solar Salt Research Center of Mokpo National University from Ministry of Oceans and Fisheries of Korea.