Premium
Dry Bean Consumption Inhibits Colorectal Tumorigenesis in Preclinical Studies: A Meta‐Analysis of Animal Studies
Author(s) -
Perera Thushanthi,
Takata Yumie,
Bobe Gerd
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.790.21
Subject(s) - colorectal cancer , carcinogenesis , medicine , meta analysis , adenocarcinoma , oncology , relative risk , confidence interval , adenoma , gastroenterology , physiology , cancer
Background Chemo‐protective effect of dry beans against colorectal tumorigenesis in humans has been proposed, but the number of studies examining this effect is limited. To evaluate whether further human studies are warranted, we conducted a meta‐analysis of preclinical studies in animals examining the relation between dry bean consumption and colorectal tumorigenesis. Methods Ten preclinical studies were included in the meta‐analysis to evaluate the effect of consumption of whole dry beans and dry bean fractions (fiber fractions, ethanol extract, and ethanol extract residue) at varying concentrations of the diet (10–75% of dry beans of the overall diet) on colorectal tumorigenesis. Tumor endpoints were incidence and multiplicity of adenocarcinoma, adenoma + adenocarcinoma, tumor, or aberrant crypt foci (ACF; only multiplicity). Risk estimates for tumors, comparing cancer‐induced rats (n=277) and mice (n=53) consuming dry beans versus cancer‐induced rats (n=173) and mice (n=52) consuming a control diet, all of which were male, were calculated using pooled risk ratios (RR) and 95% confidence intervals (CI) through a random‐effects model in STATA. For calculating risk estimates of tumor and ACF multiplicity, we calculated standardized mean differences and variation from reported means and standard errors. Results Cancer‐induced male rats or mice consuming dry beans had a lower colorectal tumor risk than those consuming control diet: colorectal adenocarcinoma incidence (RR=0.38; 95% CI: 0.20–0.74) and multiplicity (RR=0.52; 95% CI: 0.27–0.98), combined adenoma + adenocarcinoma incidence (RR=0.25; 95% CI: 0.16–0.40) and multiplicity (RR=0.52; 95% CI: 0.31–0.89), tumor incidence (RR=0.21; 95% CI: 0.11–0.43) and multiplicity (RR=0.24; 95% CI: 0.16–0.36), and ACF multiplicity (RR=0.11; 95% CI: 0.04–0.27). Conclusions Dry bean consumption inhibits colorectal tumorigenesis in male animal models of human CRC. However, long‐term dry bean CRC prevention intervention studies in humans are warranted to further elucidate the effects of daily dry bean consumption on different stages of colorectal tumorigenesis.