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The Impact of Diabetes on Typical Manifestation of Tuberculosis and the Nutritional Status
Author(s) -
Wang Qiuzhen,
Ma Aiguo,
Zhao Shanliang,
Cai Jing,
Zhang Yu,
Han Xiaohong,
Kou Tingyan,
Du Baoli,
Song Jiaqi
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.789.9
Subject(s) - medicine , diabetes mellitus , tuberculosis , lesion , gastroenterology , hypertriglyceridemia , malnutrition , sputum , incidence (geometry) , lung , surgery , pathology , triglyceride , endocrinology , cholesterol , physics , optics
It has been reported that pulmonary tuberculosis (TB) in diabetic patients (DM) presents an atypical radiographic pattern, together with an aggravated clinical manifestation. However, the results vary substantially between studies. We investigated the lung damage of the TB patients with and without DM detected by computer tompgraphic (CT) in a chest hospital from January, 2014 to June, 2015. Totally, 278 TB patients with DM (TB‐DM) and 348 TB patients without DM were recruited. The results showed that TB‐DM had a significantly higher prevalence of lung cavity and infiltrate than TB (59.0% vs 43.0%, p<0.001; 80.1% vs 69.4%, p<0.01, respectively) and more lower‐lobe lesion was observed in TB‐DM (p<0.05). TB‐DM patients had a higher incidence of haemoptysis, sputum positive, especially >10 bacilli per oil immersion field (all p<0.05). There existed sever kind of malnutrition in TB‐DM patients. Nearly 70% patients had lymphocyte reduction, nearly 30% hadanemia and hypertriglyceridemia. Also, there exsited hypoalbuminemia and hypercholesterolemia in the subjects. In conclusion, TB‐DM patients showed more severe lung damage and more frequent lower‐lobe lesion, which indicates that it is of great importance to distinguish the disease from community‐acquired pneumonia since most of the later reports are based on the results of radiographs of lower‐lobe manifestation. And malnutrition may be associated with the prevalence of TB‐DM. Support or Funding Information Supported by NSFC‐81472983