Premium
Blood Lead Toxicity is not Associated with Anemia and Iron Deficiency in Children from Bhaktapur, Nepal
Author(s) -
Chandyo Ram K,
Shrestha Binob,
Zhao Beibo,
Ulak Manjeswori,
Shrestha Prakash S,
Shrestha Rita,
Bodhidatta Ladaporn,
Mason Carl,
Shrestha Laxman,
Strand Tor,
Shrestha Sanjaya
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.786.2
Subject(s) - anemia , iron deficiency , medicine , hemoglobin , ferritin , soluble transferrin receptor , malnutrition , iron deficiency anemia , toxicity , physiology , pediatrics , immunology , iron status
Background Anemia, particularly iron deficiency anemia, is still common among children from resource poor settings. Besides inadequate intake of iron rich foods, lead toxicity may be an important underlying cause for anemia and iron deficiency. However, there are lack of data on lead toxicity and its relation with anemia and iron deficiency. Methods Blood samples were collected from 225 healthy children at 15 months of age who were participating in a cohort study on malnutrition and interaction with enteric infection (MAL‐ED). Blood was analyzed for leads hemoglobin, plasma ferritin, and transferrin receptor concentrations. Results The prevalence of anemia (Hb <11 g/dl) was 51% and 54% of children were iron deficient as indicated by low ferritin and/or high transferrin receptor concentrations. The mean (SD) blood lead concentration was 12.8 μg/dl (7.6) and 60% of children were having high lead concentrations (>10 μg/dl). Sixty‐three percent of the anemic children had high blood lead concentrations compared with 56% among the non‐anemic children ( p =0.2). Similarly, high lead concentration was found among 61% children with iron deficiency and in 54% of the non‐deficient (p=0.2). Conclusion Anemia, iron deficiency and high blood lead concentration was common among healthy infants in Bhaktapur. However, higher lead concentration was not associated with anemia and iron deficiency. Support or Funding Information The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL‐ED) is carried out as a collaborative project supported by the Bill and Melinda Gates Foundation, The Foundations for the NIH and the National Institute of Health/ Fogarty International Center. The authors thank the staff and participants of the MAL‐ED Network Project for their important contributions.