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Genetic Characterization of Programmed Cell Death in Aneuploid Yeast Cells
Author(s) -
Sanborn Matthew,
Timmel Victoria,
Barrios Jessie,
McBride Trevor,
Pinches Robert Seth,
Austriaco Nicanor
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.774.13
Subject(s) - aneuploidy , saccharomyces cerevisiae , genome instability , biology , yeast , programmed cell death , chromosome instability , genetics , cell , mitosis , cell cycle , microbiology and biotechnology , dna damage , apoptosis , dna , gene , chromosome
Aneuploidy is the genetic state of a cell that has a chromosomal number that is not an exact multiple of the haploid complement. It is a leading cause of spontaneous abortions and of mental retardation in humans, and is a characteristic defect in cancer. Yeast cells that are aneuploid manifest a diversity of phenotypes including cell cycle defects, genomic instability, protein imbalance, chaperone stress and proteotoxicity. We are investigating the links between aneuploidy on the budding yeast, Saccharomyces cerevisiae and programmed cell death. We have shown that aneuploid yeast cells are more sensitive to ethanol‐induced cell death. In addition, we have also shown that caloric restriction protects aneuploid yeast from programmed cell death. Support or Funding Information In addition to funding from the RI‐INBRE Program, our laboratory is supported by grant NIGMS R15 GM110578, awarded to N. Austriaco.