Premium
Induction of apoptosis in carcinoma cells: Perhaps it is right way to kill the metastatic process
Author(s) -
Basu Subhash,
Basu Manju,
Ma Rui,
Moskal Joseph R
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.774.10
Subject(s) - apoptosis , cancer research , cancer cell , programmed cell death , cancer , suicide gene , biology , maspin , metastatic breast cancer , breast cancer , chemistry , metastasis , biochemistry , genetic enhancement , gene , genetics
The normal cells in their life cycle die through apoptosis (programmed cell death or degradation of genomic DNA). On the other hand, metastatic cancer cells die mostly by Necrosis where toxic gene products come out through the holes on the cancer cell surface to induce necrotic death‐effect on normal cells. In cancer cells, the following chemical could inhibit blocked steps for apoptosis: cis‐platin (commonly used drug for testicular cancer treatment), Betulinic acid (a naturally occurring triterpene), L‐PPMP, D‐PDMP (inhibitor of GlcT [ceramide: glucosyltransferase]), Tamoxifen (commonly used drug for breast cancer treatment), and Melphalan (Golgi bodies scrambler). When three clones of metastatic breast cancer cells (SKBR‐3, MCF‐7 and MDA468) were treated with these apoptotic reagents separately, they induced apoptosis [activated Caspases (‐3, ‐8, or ‐9)] and down‐regulated the genes for cancer markers like sialo‐LeX (determined by DNA‐microarray studies). Targeted application of apoptotic chemicals to kill the cancer cells would be an ideal way for breast cancer therapy. Support or Funding Information Supported by NIH‐CA‐14764 and NIH‐NS‐18005