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The Sp1 in Astrocyte plays an important role in Neurogenesis
Author(s) -
Hung JanJong,
Chang WenChang
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.756.4
Subject(s) - astrocyte , neurogenesis , biology , neuroscience , microbiology and biotechnology , neuron , central nervous system
Sp1 as a transcriptional factor regulates many genes related to various physiological conditions such as cellular survival, death, and development, and it also involves in many diseases such as cancer. In the past, we found that Sp1 could be up regulation through H 2 O 2 ‐mediated IRES‐dependent translational pathway to protect neuron from ischemic damage, indicating that Sp1 might be crucial for the physiology or pathology of brain. Our recent data indicate that higher level of Sp1 is expressed in astrocyte compared to neuronal cells, implying that Sp1 might be critical for the function of astrocyte. To elucidate the function of Sp1 in astrocyte, we constructed a conditional functional knockout of Sp1 specific in astrocyte. Our recent results reveal that loss of Sp1 in astrocyte affect the morphology and function of astrocyte, leading neuron loss and synapse formation defect, subsequently affect the abilities of learning and excise. To address the molecular mechanism(s) show that many genes in astrocyte regulated by Sp1 control the levels of glutamate and other growth factors, which are important for neuron function and survival. In conclusion, Sp1 in astrocyte regulates many genes related to neurogenesis.