Premium
Different expression of miRNA in the elderly with cognitive impairment and control group in aluminum exposed mining area
Author(s) -
Ma Huina,
Huang Hehua,
Tang Lingling,
Zhou Shanjin,
Chen Bingpu,
Ling Yanwu
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.745.6
Subject(s) - microrna , disease , dementia , cognitive impairment , cognition , reverse transcriptase , medicine , real time polymerase chain reaction , mini–mental state examination , oncology , bioinformatics , biology , polymerase chain reaction , gene , psychiatry , genetics
Alzheimer's disease (AD) is a nerve degenerative disease, it's intimately connected with the genetic and environmental factors. Previous work showed high aluminum exposure may be a risk factor of AD in the mining area. The dysregulation of miRNA expression has been found to be closely associated with AD. Cognitive function was measured by mini‐mental state examination(MMSE). The contents of trace elements (Al) in blood were determined using ICP‐AES. We analyzed the expression of miRNAs in peripheral blood of a total of 360 Cognitive impairment group (n=156) and healthy controls (n=204) by quantitative reverse transcriptase polymerase chain reaction (qRT‐PCR). Data assays show 7 miRNAs displayed significantly different expression levels in Cognitive impairment group serum compared with controls in aluminum mining area. Indicate that deregulated miRNAs in blood might be used as biomarkers in the diagnosis of early AD or other dementia disease. Support or Funding Information Supported by National Natural Science Foundation of ChinaNO.31560294