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Cervical C2 hemisection acutely induces swallow hyperreflexia
Author(s) -
Huff Alyssa,
Greene Clint,
Cheffer Kimberly A,
O'Steen Wilbur A,
Howland Dena R,
Pitts Teresa
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.728.6
Subject(s) - medicine , swallowing , breathing , airway , anesthesia , pharyngeal muscles , spinal cord , spinal cord injury , anatomy , surgery , psychiatry
The effects of cervical hemisection on swallow have not been determined. We hypothesized that cervical hemisection would increase swallow excitability and shift the pattern of swallow breathing coordination to maintain pharyngeal clearance. Electromyograms of the mylohyoid, geniohyoid, thyrohyoid, thyroarytenoid, thyropharyngeus, cricopharyngeus and diaphragm (costal and crural) muscles were recorded in anesthetized, spontaneously breathing anesthetized cats prior to and after a C2 hemisection. Swallow was elicited by infusion of 3ccs of water into the oropharynx. Acute C2 cervical hemisection significantly increased EMG amplitudes across all upper airway muscles during swallow, and swallow frequency increased from 3.3 ± 1.2 to 8 ± 1.4 per infusion. Significant changes in swallow‐breathing coordination were noted with all swallows occurring in E1 (as opposed to late E2), significantly increasing the risk for potential aspiration. These results support a theory of spinal cord inhibition/modulation of the swallow pattern generator and upper airway muscle excitability, as well as the importance of its role in swallow/breathing integration. Support or Funding Information Supported by R00‐HL 111215, The Kentucky Spinal Cord and Head injury Trust, The Commonwealth of Kentucky Challenge for Excellence, the Rebecca F Hammond Trust and RCS‐VA RR&D B9249S. The contents of this abstract do not represent the views of the DVA or US government.