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Hypercapnic and hypoxic ventilatory response in streptozotocin‐model of Alzheimer's disease during wakefulness
Author(s) -
Vicente Mariane C,
Bícego Kênia C,
Carrettiero Daniel C,
Gargaglioni Luciane H
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.728.1
Subject(s) - hypercapnia , wakefulness , streptozotocin , ventilation (architecture) , medicine , anesthesia , endocrinology , respiratory system , diabetes mellitus , electroencephalography , mechanical engineering , psychiatry , engineering
Neurodegenerative diseases such as Alzheimer's may impair breathing function; however, how these breathing deficits occur is not completely understood. Therefore, it is important to evaluate how Alzheimer's disease (AD) can alter breathing activity. In light of this, we used an animal model for sporadic AD induced by intracerebroventricular (icv) injection of streptozotocin (STZ, 4 mg/kg) in adult male Wistar rats. After 30 days of STZ treatment, memory impairment (using Y‐maze and Barnes maze tests) was analyzed to validate STZ model. Then, ventilation (V E ) was measured by whole‐body plethysmograph (barometric technique) during wakefulness and sleep under normocapnia, hypercapnia and hypoxia. STZ treatment caused learning and memory impairment and increased hypercapnia ventilatory response during wakefulness (V E STZ = 2460.9 ± 83.7 vs V E Vehicle= 1758.5 ± 234.3 mL.Kg −1 .min −1 ) due to an effect on both tidal volume and breathing frequency. No difference was observed in the respiratory variables between STZ and vehicle groups during room air conditions (V E STZ = 775.5 ± 56.1 vs V E Vehicle = 651.3 ± 56.1 mL.Kg −1 .min −1 ) and hypoxia (V E STZ = 1073,2 ± 53,7 vs V E Vehicle =1085.9 ± 127.2 mL.Kg −1 .min −1 ) in wakefulness. Our data suggest that sporadic AD animals present an increased CO 2 but no O 2 chemosensitivity. Support or Funding Information FAPESP and CNPq