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Resveratrol Protects Against Hyperoxia‐Induced Airway Hyperreactivity in Neonatal Rats
Author(s) -
SOPI RAMADAN B,
Reçica Shkëlzen,
Lajçi Azem,
Kryeziu Islam,
Thaçi Qëndrim,
Dreshaj Ismail A,
Basholli Mimoza
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.726.8
Subject(s) - hyperoxia , resveratrol , methacholine , medicine , airway , anesthesia , lung , endocrinology , pharmacology , respiratory disease
Neonatal hyperoxia is associated with airway hyperreactivity and lung injury. We tested the hypothesis that supplementation of resveratrol will overcome the increased contractile responses of tracheal smooth muscle exposed to hyperoxia. Tracheal cylinders were obtained from Wistar rat pups (P12) exposed to hyperoxia (≥ 95% O2) or room air for seven days. These cylinders were used to study contractile responses of airway smooth muscle (ASM) evoked by methacholine (MCh, 10‐8 – 10‐4 M) in absence or presence of resveratrol (100 μM). MCh induced dose‐dependent contractile responses of ASM. The contractile responses towards MCh were significantly higher in preparations obtained from animals exposed to hyperoxia as compared to those obtained from control animals exposed to room air. The enhanced contractile responses in hyperoxic tissues were significantly attenuated in presence of resveratrol. The results of this study revealed that resveratrol diminishes the airway hyperreactivity induced by hyperoxia and we speculate that the use of resveratrol might be an effective therapeutic approach to prevent the adverse effects of hyperoxia. Support or Funding Information Supported by MEST