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Preterm birth is associated with a decrease in cervicovaginal Liners during second trimester in Mexican women.
Author(s) -
RodriguezMartin Pedro,
PalaciosGonzalez Berenice,
VadilloOrtega Felipe
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.723.4
Subject(s) - pregnancy , lactobacillus , obstetrics , medicine , first trimester , gestation , gynecology , preterm labor , bacterial vaginosis , neonatal mortality , biology , infant mortality , bacteria , genetics
The vaginal microbiota plays an important rol during gestation. The presence of cervicovaginal infections during pregnancy has been associated to preterm labor. Prematurity is associated to high neonatal morbidity and 60–80% of all neonatal deaths. The aim for the present study was to characterize changes throughout pregnancy in Lactobacillus iners abundance of women who developed preterm birth. Women were selected according outcome and two groups were analyzed: 1. Term outcome (n=30) (T) and 2. Preterm outcome (n=30) (P). Cervicovaginal swabs were collected and whole genomic DNA was extracted and Lactobacillus ssp and L. iners were analyzed by RT‐PCR. Women who delivered at preterm had a significant decrease in L. ssp y L. inners in the second trimester. Our data revealed that the composition of the vaginal microbiota is a dynamic process, which means that the microbiota is modified in several points across the pregnancy.