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Berlin Questionnaire is a Useful Tool to Identify Risk of Obstructive Sleep Apnea in Metabolic Syndrome Patients
Author(s) -
Cepeda Felipe Xerez,
Virmondes Leslie,
Rodrigues Sara,
DutraMarques Akothirene C.B.,
Carvalho Jefferson C.,
ToschiDias Edgar,
Alves Maria Janieire N.N.,
Rondon Maria Urbana P.B.,
LopesVicente Wanda R.P.,
Hussid Maria Fernanda,
LorenziFilho Geraldo,
Trombetta Ivani C.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.700.3
Subject(s) - medicine , obstructive sleep apnea , polysomnography , gold standard (test) , predictive value , metabolic syndrome , sleep apnea , risk factor , apnea–hypopnea index , apnea , pediatrics , obesity
Obstructive sleep apnea (OSA) is a risk factor frequently present in patients with metabolic syndrome (MetS). Despite of MetS, moderate and severe OSA has been associated with cardiovascular diseases, increasing 80% the risk of cardiovascular event. The gold standard diagnostic method for OSA is the overnight polysomnography (PSG), that is in general not accessible. The aim of the present study was to evaluate whether Berlin Questionnaire (BQ) is a good tool for assessing the risk of OSA in patients with MetS. We submitted 97 patients, untreated and newly diagnosed with MetS (ATP‐III) to a PSG. OSA was characterized by apnea‐hypopnea index (AHI). BQ was administered before PSG and we evaluated the sensitivity, specificity, positive and negative predictive values and accuracy. Of the 97 patients with SMet, 81 patients had OSA, being 47 (48.5%) with moderate and severe OSA. For all SMet with OSA (AHI>5 events/hour), the BQ showed good sensitivity (0.65) and fair specificity (0.38) with a positive predictive value of 0.84, negative predictive value of 0.18 and accuracy of 84%. Similarly, for moderate‐severe OSA (AHI>15 events/hour) we found good sensitivity (0.73) and fair specificity (0.40). Interestingly, for severe OSA (AHI>30 events/hour), there was a very good sensitivity (0.91) and moderate specificity (0.42). In conclusion, BQ is a good predictor for the screening of OSA in MetS patients in general, but it is a very good tool for predicting severe OSA. Support or Funding Information Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP) #2011/175336, #2015/175336 and #2016/168317