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Reduced Uterine Perfusion Pressure‐Induced Preeclampsia Acquires Salt‐Sensitivity Characteristics in Postpartum
Author(s) -
Matsuura Taku,
Shinohara Keisuke,
Kishi Takuya,
Tsutsui Hiroyuki,
Hirooka Yoshitaka
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.692.4
Subject(s) - preeclampsia , medicine , blood pressure , perfusion , gestation , pregnancy , mean arterial pressure , aorta , endocrinology , cardiology , heart rate , biology , genetics
Background Preeclampsia, a hypertensive disorder during pregnancy, occurs in 3% to 8% of pregnancies, and the risk of future cardiovascular diseases is 2 to 4 times higher in women with preeclampsia than in women without. Women with a history of severe preeclampsia also have a tendency toward salt‐sensitive hypertension. However, it is not yet clear whether preeclampsia leads to salt‐sensitive hypertension later in life as an acquired characteristic or as a manifestation of the original predisposition. We hypothesized that preeclampsia results in postpartum salt‐sensitive hypertension as an acquired characteristic. Methods and results We established a rat with reduced uterine perfusion pressure model (RUPP) as a model of acquired preeclampsia, by placing a silver clip (0.203‐mm ID) around the aorta above the iliac bifurcation and branches of bilateral ovarian arteries (0.100‐mm ID). Pregnant Sprague‐Dawley rats were divided into two groups that underwent the RUPP operation or sham operation (SHAM) at day 14 after gestation. Mean arterial pressure (MAP) at day 19 after gestation was significantly higher in RUPP than in SHAM rats (116 ± 4 mmHg vs. 100 ± 5 mmHg, n's=7 and 3, respectively; p<0.05). At 2 weeks postpartum, MAP similarly returned to normal levels between RUPP and SHAM rats (92.9±3.0 mmHg vs. 87.4±5.4 mmHg, n=6 and 4). At 3 weeks postpartum, a high‐salt (8% NaCl) diet for 1 week was initiated. Surprisingly, the high‐salt diet further increased MAP in RUPP (110.8±3.2 mmHg, n=6), compared to SHAM (99.8±5.0 mmHg, n=4). Conclusion Preeclampsia results in postpartum salt‐sensitive hypertension as an acquired characteristic.