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Cardioprotective effects of hydroalcoholic extract of Terminalia capatta in isolated perfused rat hearts.
Author(s) -
TorresTirado Jose David,
Pérez Gabriela,
Sanchez Eugenia,
Estrada Alejandro,
Zacarias Alejandra,
Leon Angel
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.680.7
Subject(s) - terminalia , traditional medicine , medicine , pharmacology , ischemia , cardiology
The use of traditional medicinal plants in prevention and treatment of different illnesses is a comun practice in the world. Mexico has a long traditional plants applications since ancient times. Terminalia catappa is used in the empirical treatment of skin illness, digestive diseases and in a recent study the seed extract show cardio protective effects. The aim of this work was to test the cardioprotective effect of hydroalcoholic extract of Terminalia capatta leaves. The extract was oral administrated one time a day in wistar rats during seven days after its were sacrificed to test ten min ischemia and ten min reperfusion in Langendorff isolated heart technique. Results showed an important decrease in loss of contraction of the left ventricular pressure of 20 % vs control. The histology showed an 16% decrease in the infarct size vs control. Terminalia capatta extract showed an important cardioprotective effects in our model. Support or Funding Information This work was supported by grants from UASLP (FAI 2014 to JTT and 2016 to GP)