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ANTITHROMBOTIC ACTIVITY OF NEW POTASSIUM SALT 2‐[3‐BROMINE‐1‐(THIETANIL‐3)‐1,2,4‐TRIAZOLIL‐5‐THIO]ACETIC ACID
Author(s) -
Samorodov Aleksandr Vladimirovich,
Kamilov Felix Khusainovich,
Klen Elena Edmundovna,
Khaliullin Ferkat Adelzyanovich,
Khalimov Almaz Radikovich
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.674.14
Subject(s) - medicine , acetic acid , aspirin , antithrombotic , in vivo , pharmacology , chemistry , biochemistry , biology , microbiology and biotechnology
The previous findings in vitro show high antiaggregation activity of newly synthesized potassium salt of 2‐[3‐bromine‐1‐(thietanil‐3)‐1,2,4‐triazolil‐5‐thio]acetic acid (substance I). The current findings are received in vivo on the model of collagen‐adrenaline thrombosis according to G.S. Di Minno subject to the FASEB Statement of Principles for the use of animals in research and education. Efficacy endpoint is the number of survived animals in comparison with the test group and comparator agents since the injection into the tail vein suspended matter of collagen and adrenalin upto the moment of death or during 14 days of monitoring. The survival analysis was carried out with the help of Kaplan‐Meier method. The difference in survival between the groups was assessed with the help of Wilkonson criterion generalized by Gehan. Intraperinoneal injection of the new secondary 1,2,4‐triazole reduced mortality in lab mice by 1,3 times (p<0,01) in comparison with the camparator agents ( table 1). Thus, potassium salt of 2‐[3‐bromine‐1‐(thietanil‐3)‐1,2,4‐triazolil‐5‐thio]acetic acid is a potential antithrombotic agent. 1 The survival rate in the modeling of the collagen‐adrenaline thrombosis, M±SDSubject Control Pentoxifylline Aspirin Substance ILifetime, h 2,0±1,8 165,8±157,6 * 172,6±102,8 * 206,9±135,2 *p 2 <0,001p 3 <0,005* p 1 <0,01 ‐ control vs experimental group; p2 ‐ substance I vs pentoxifylline, p 3 ‐ substance I vs aspirin, χ 2 =33,1.