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Effects of sequential exposure to ethanol and methamphetamine on tissue contents of dopamine, serotonin and glutamate in Wistar rats
Author(s) -
Almalki Atiah H.,
Das Sujan C.,
Alshehri Fahad S.,
Althobaiti Yusuf S.,
Sari Youssef
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.661.2
Subject(s) - meth , methamphetamine , dopamine , striatum , serotonin , glutamate receptor , ethanol , hippocampus , neurotransmitter , chemistry , pharmacology , medicine , endocrinology , biochemistry , central nervous system , receptor , monomer , organic chemistry , acrylate , polymer
Compulsive ethanol intake and methamphetamine (METH) are considered as a major public health issue. Ethanol and METH exposures have been associated with changes in neurotransmitters levels in several central brain regions. However, there is little known about the co‐abuse of ethanol and METH on glutamate, GABA, dopamine and serotonin tissue contents in striatum and hippocampus. In this study, we investigated the effects of sequential exposure to ethanol and METH on these neurotransmitters. Young adult male Wistar rats were orally gavaged with either ethanol (6 g/kg) or water for seven days. On Day 8, rats were administered high dose of METH (10 mg/kg, i.p. every 2 h × 4). We revealed additive effects of ethanol and METH on the reduction of dopamine tissue contents in striatum as well as reduction of serotonin tissue contents in striatum and hippocampus as compared to each drug administered alone. Moreover, glutamate concentrations were increased in ethanol and METH group compared to ethanol administrated alone but decreased compared to METH administered alone group in striatum. These findings suggest that ethanol has an additive effect to METH on several neurotransmitters tissue contents in striatum and hippocampus. Support or Funding Information This work was supported in part by Award Number R01AA019458 (Y.S.) from the National Institutes on Alcohol Abuse and Alcoholism and by fund from the University of Toledo.