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Animating external magnetic guidance of intrathecally delivered gold‐coated nanoparticles to treat intramedullary spinal tumors
Author(s) -
Orland Adriana,
Brennan Kevin,
Lebowicz Leah,
Wellman Christa,
Mehta Ankit
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.659.21
Subject(s) - medicine , neurosurgery , radiation therapy , spinal cord , intramedullary rod , spinal cord tumor , surgery , psychiatry
Intramedullary spinal tumors (IMSCTs) are rare neoplasms in the central nervous system (CNS), accounting for 2–4% of all CNS tumors (Tobin et al., 2015). Astrocytomas, a common type of IMSCT, are infiltrative and do not lie in a clear plane of dissection between the normal spinal cord tissue and the tumor. This makes removal of the tumor through surgery difficult. Due to limitations in current surgical options, along with the adverse effects of chemotherapy and radiotherapy, the use of external magnets to guide intrathecally delivered gold‐coated nanoparticles has been proposed as a less invasive treatment with fewer side effects for eliminating astrocytomas (Tobin et al., 2015; Leushen et al., 2014). To accompany the emergence of this technique an animation using anonymized patient data was developed to create a new resource to both explain and to teach grant committees, surgical residents, and surgical faculty about the technique. A qualitative survey was developed using Qualtrics to provide, residents, faculty, and researchers at the University of Illinois at Chicago Neurosurgery and Neurology Departments an opportunity to provide comments. Likert scale questions and qualitative comments confirmed that the animation was effective in accurately portraying the technique and as a new valuable visual aid for neurosurgeons. This new resource will continue to help explain the procedure in anticipated upcoming clinical trials. Magnetic Drug Targeting (MDT) of Gold‐Coated NanoparticlesAn overview of MDT of gold‐coated nanoparticles to treat intramedullary spinal tumors. The left inset depicts the injection site of the nanoparticles to the lumbar spine. The right inset depicts the use of external magnets to concentrate nanoparticles containing anti‐cancer drug, Doxorubicin, to the site of the spinal tumor. The spine was segmented from anonymized patient data using Materialise Mimics. Not drawn to scale.