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Serum concentration of appetite regulating hormones in infants according to the type of feeding. Preliminary data
Author(s) -
VasquezGaribay Edgar M,
LarrosaHaro Alfredo,
GarcíaArellano Samuel,
MuñozEsparza Nelly,
GuzmánMercado Elizabeth,
MuñozValle Francisco,
RomeroVelarde Enrique
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.650.25
Subject(s) - appetite , ghrelin , medicine , hormone , peptide yy , leptin , endocrinology , breastfeeding , neuropeptide y receptor , physiology , obesity , receptor , pediatrics , neuropeptide
Hunger is an internal stimulus influenced by ingestion of food. There are hormones that play a role in the regulation of food intake and body composition with signaling hunger and satiety through hypothalamic receptors. One hypothesis has proposed that exclusively breastfed (EBF) infants have the ability to self‐regulate his energy intake according to his needs. Another has indicated that the appetite regulating hormone profile differs between EBF and formula fed (FF) infants. Therefore, the purpose is to present data on the serum concentration of appetite hormones in infants according to the type of feeding. Methods In a cohort observational study, with a non‐random sample at a concentration site, 70 infants of mothers who entered in the physiological puerperium room of the Nuevo Hospital Civil de Guadalajara, who met the inclusion criteria and signed Informed consent were included. Fasting blood samples were obtained from infants in Vacutainer® tubes with anticoagulant EDTA treated with protease inhibitors aprotinin and dipeptidyl peptidase‐4 inhibitor. The hormones leptin, ghrelin, peptide‐YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) were analyzed with the ELISA method. The comparison between groups was performed with ANOVA, Post‐Hoc tests and Student's t test for independent samples or with Mann‐Whitney U. The Research and Bioethics Committee of the New Civil Hospital of Guadalajara authorized the protocol. Results Of the total sample at four months of age (70), 27 infants were EBF, 25 partial breastfeeding (PBF) and 18 FF. The mean serum concentration of ghrelin (932 pg/mL), leptin (2.2 ng/mL) and GLP‐1 (31.6 pM) did not show significant differences between the three groups. ANOVA showed significantly different serum concentrations of PYY among EBF infants (500 pg/mL), PBF infants (449 pg/mL) and FF infants (431 pg/mL), p=0.039. The largest difference was observed among EBF infants vs FF infants, p=0.012. GLP‐1 concentration was greater in PBF infants (40.3 pM) than FF infants (24.5 pM), p=0.055. Leptin concentration was lower in EBF infants (1.9 ng/mL) than PBF and FF infants (2.5 and 2.3 ng/mL, respectively), no significant difference. Conclusion These preliminary results show a differentiated character in two appetite regulating hormones (PYY and GLP‐1) according to the type of feeding in four months old infants. It is likely that with increasing sample size leptin also shows a significantly lower concentration in EBF infants. Support or Funding Information Project supported by the National Council of Science and Technology of Mexico (234158)