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Pterostilbene inhibits adipocyte differentiation by targeting CHOP10 in 3T3‐L1
Author(s) -
Kim KuiJin,
Seo YoungJin,
Koh EunJeong,
Choi Jia,
Hwang JiHyun,
Lee YeonJoo,
Song JiHyeon,
Chei Sungwoo,
Choi SeoYun,
Park MinKi,
Lee BooYong
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.646.43
Subject(s) - pterostilbene , adipogenesis , adipocyte , microbiology and biotechnology , 3t3 l1 , chemistry , biology , biochemistry , in vitro , resveratrol , adipose tissue
Pterostilbene has been shown that attenuates adipogenesis through the regulation of adipogenesis markers. However, it has not been shown whether pterostilbene affects the mitotic clonal expansion (MCE) during adipogenesis. We therefore aimed to demonstrate the detail mechanism of pterostilbene on adipogenesis of 3T3‐L1. Consistent with previous report, our result showed pterostilbene suppressed the expression of C/EBPα, PPARγ and aP2. In addition, we observed that pterostilbene increased the MCE‐associated proteins CHOP10 and subsequently inhibit the progression of next stage of adipognesis. These results indicated that pterostilbene may repress adipocyte differentiation through the activation of CHOP10 expression prior to entering into the MCE. Together, we demonstrated that pterostilbene suppresses the initiation of MCE via retaining of CHOP10 expression during adipocyte differentiation of 3T3‐L1.