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Prevalence of Lactose Intolerance in Patients on Proton‐pump inhibitors
Author(s) -
Rana SatyaVati,
Pruthvi CR,
Malik Aastha,
Sinha Saroj Kant,
Kochhar Rakesh
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.645.25
Subject(s) - small intestinal bacterial overgrowth , hydrogen breath test , medicine , gastroenterology , lactose intolerance , lactose , lactase , breath test , irritable bowel syndrome , food science , chemistry , helicobacter pylori
BACKGROUND Proton‐pump inhibitors (PPIs) are most effective drugs available to reduce gastric acid secretion. Their administration provokes dysbiosis of small intestinal bacterial flora, which exacerbates non‐steroidal anti‐inflammatory drug‐induced small intestinal injury. This injury to small intestine may cause secondary lactase deficiency leading to lactose intolerance. AIM To study the prevalence of Small Intestinal Bacterial Overgrowth (SIBO) and Lactose Intolerance (LI) in patients taking PPIs MATERIALS & METHODS 132 patients taking PPI only for more than 3 months and attending Gastroenterology Clinic at PGIMER, Chandigarh were enrolled.135 age & sex matched healthy controls who gave consent for study were also enrolled. Non‐invasive glucose & lactose hydrogen breath tests were done after overnight fast for measurement of SIBO and LI respectively. SIBO was measured by analysis of end‐expiratory breath for 2 hours after giving 75g glucose dissolved in 450ml water. LI was measured by analysis of end‐expiratory breath for 4 hours after giving 25g lactose dissolved in 250 ml water. RESULTS Mean ± SD of age in patients and controls was 42.1 ± 12.9 & 41.7 ± 10.2 years respectively. %age of SIBO in patients, 18/132(13.6%) was significantly higher (<0.05) as compared to controls 1/135 (0.74%). LI was also higher (p<0.05) in patients (62.8%) as compared to controls (34.8%). Moreover, prevalence of LI was higher among SIBO+ve patients (12/18; 66.7%) as compared to SIBO−ve patients (6/18 : 33.3%) CONCLUSION This study indicates that lactose intolerance is in more number of patients taking PPIs and this would have been due to increased small intestinal bacterial overgrowth in these patients Support or Funding Information Department of Gastroenterology, PGIMER, Chandigarh, India