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Single Nucleotide Polymorphisms in FADS2, CETP and LPL and the Associations with Blood Lipids and Fatty Acids Differ in a Sex‐Specific Manner
Author(s) -
Klingel Shan Lee,
Roke Kaitlin,
Mutch David M
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.644.11
Subject(s) - fads2 , single nucleotide polymorphism , fatty acid , arachidonic acid , docosahexaenoic acid , blood lipids , fatty acid desaturase , biology , genotype , triglyceride , lipid metabolism , fatty acid metabolism , endocrinology , medicine , cholesterol , biochemistry , polyunsaturated fatty acid , gene , enzyme
Objective Blood lipid and fatty acid profiles are strongly influenced by diet and genes. The current investigation examined if common single nucleotide polymorphisms (SNPs) in genes linked to fatty acid metabolism are associated with blood lipids and fatty acids in a sex‐specific manner. Methods Fasted serum samples were used to analyze blood lipids and red blood cells (RBCs) were used to measure fatty acid profiles in 94 adults (19–30 yrs). A panel of 23 SNPs in 17 genes linked to fatty acid metabolism were examined by linear regression for genotype‐sex interactions. Results HDL‐c levels were higher in women than men, while the total cholesterol/HDL‐c ratio showed the opposite relationship (p<0.01). Numerous sex‐specific differences in RBC fatty acids, as well as various desaturase/elongase activity estimates, were also observed (p<0.01). The following SNPs showed statistically significant genotype‐sex interactions: 1) rs328 in LPL with HDL‐c levels (p interaction =0.0478), 2) rs1800775 in CETP with the total cholesterol/HDL‐c ratio (p interaction =0.0329), and 3) rs174575 in FADS2 with estimated desaturase activity (p interaction =0.048). Further, rs174537 in FADS1 and rs3211956 in CD36 were significantly associated with RBC arachidonic acid and docosahexaenoic acid levels, respectively, but not in a sex‐specific manner. Conclusion Our findings suggest that studying genetic variants may help elucidate sex‐specific risks in cardiometabolic complications. Consequently, this information can be used to guide the development of sex‐specific dietary recommendations to prevent and/or mitigate cardiometabolic risk. Support or Funding Information Supported by OMAFRA.