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Anti‐Obesity Effects of Solar Salt Prepared from Concentrated New Sea Water on 3T3‐L1 Adipocytes
Author(s) -
Park KunYoung,
Park EuiSeong,
Ju Jaehyun,
Choi ShinIl
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.643.20
Subject(s) - lipogenesis , chemistry , adipogenesis , medicine , lipolysis , food science , endocrinology , adipose tissue , biology , biochemistry
The anti‐obesity effect of Korean solar salt manufactured from concentrated new sea water on 3T3‐L1 adipocytes was studied. Our experimental groups consisted of S1 (conventionally manufactured solar salt by mixture of concentrated old‐ and new sea water), S2 (charcoal‐ and magnetic filtered during S1 preparation), S3 (solar salt made by concentrated new sea water), and S4 (charcoal‐ and magnetic filtered during S3 preparation). S3 suppressed lipid droplet formation in the differentiated adipocytes (oil‐red O staining), reduced secretion of leptin. Also, S3 significantly suppressed gene expression of lipogenesis‐ and adipogenesis‐related factors (PPARγ, SREBP‐1c, C/EBPα, LXR, LPL, FAS, DGAT and MTP; p<0.05), while promoting β‐oxidation‐related factors (PPARα and CPT‐1). Taken together, S3 was found to have anti‐obesity efficacy by suppression of lipogenesis and adipogenesis and promotion of β‐oxidation‐based lipolysis, probably owing to different processing methods to eventually lead to changes in mineral composition of the salt. Thus, a processing method of solar salt affects the anti‐obesity effect of the product. Support or Funding Information This work was supported by a grant 20130290 to Solar Salt Research Center of Mokpo National University from Ministry of Oceans and Fisheries of Korea.