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Obesity and Weight Loss Pre‐Kidney Transplantation
Author(s) -
Tantisattamo Ekamol
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.643.13
Subject(s) - transplantation , medicine , overweight , obesity , weight loss , kidney transplantation , weight change
Background Weight loss in obese patients is generally required to become eligible for kidney transplantation; however, but followed‐up data pre‐transplantation is limited. Methods Kidney transplant recipients in 2015 were consecutively reviewed. Weight, height, and BMI were obtained at the time of kidney transplantation and yearly up to 6 years pre‐transplantation. Results A total of 70 patients were included. Mean age was 52.7±1.4 years (mean±SEM) and 41 patients were male (58.6%). Mean weight at the time of transplant was 81.22±2.28 kg (42–132.3) and BMI was 27.64±0.67 kg/m2 (16.6–48.3) kg/m 2 . The majority of the patients (38.6%) were overweight and 1/3 were obese (BMI≥30 kg/m 2 ). The remaining had normal weight. All patients had ≥1‐measured weight at 1‐year pre‐transplantation and the followed‐up weight ranged 1–6 years pre‐kidney transplantation. Compared to non‐obese patients, obese patients appeared to lose more weight ranging from 4.47 kg at 1‐y pre‐transplant to 23.62 kg at 6‐year pre‐transplantation with statistical significance at 2, 3, 5, and 6 years pre‐transplantation (p=0.0001, 0.0062, 0.0020, and 0.0154, respectively; Figure 1). In obese patients with weight loss, mean weight change (ΔWt = weight at the time of transplant – weight at 1 to 6 years pre‐transplant; −ΔWt) trended to decrease from 6‐ through 1‐year pre‐transplantation indicating progressive weight loss toward the time of kidney transplantation. Similarly, obese patients with weight gain trended to have decrease in mean weight change (+ΔWt) during follow up from 6‐year pre‐transplant toward the time of transplantation ( Figure 2). Conclusions During pre‐kidney transplant waiting time, obese patients trend to lose more weight than non‐obese patients. Additionally, more weight loss or less weight gain in obese patients who losing and gaining weight, respectively were progressive toward the time of kidney transplantation. Therefore, obesity should not automatically exclude the patients from becoming kidney transplant candidates.