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Presence of a Risk FTO Polymorphism in Young Adults from Northwestern Mexico and its Association with Biomarkers of Overweight and Obesity
Author(s) -
AstiazaranGarcia Humberto,
Cid Alejandro RendonDel,
UriasCazarez Esmeralda,
PachecoMoreno Bertha I,
MoralesFigueroa Gloria Guadalupe,
AnduroCorona Ivan
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.642.12
Subject(s) - obesity , overweight , anthropometry , calorie , medicine , fto gene , endocrinology , allele , snp , polymorphism (computer science) , single nucleotide polymorphism , biology , genotype , genetics , gene
Obesity is currently one of the most important public health problems worldwide, and more than 3 million deaths were attributed in 2014. Genetics can explain in part the interaction between obesity and its risk factors, therefore our objective was to explore the risk FTO polymorphism SNP rs8050136 and its possible association with obesity, diet, metabolic condition and physical activity. The study design was cross‐sectional analytic. We included 51 young adults and measured anthropometry, body composition (BIA), dietary intake and physical activity, and fasting blood samples were drawn. We amplified and sequenced one FTO fragment including the rs8050136 SNP where allele A has been associated with obesity risk because carriers had a higher calorie intake. Our results show that allele A was found in heterozygous form in 33.33 % of the subjects and they had a tendency to increase body fat percentage (0.138), increased body weight (p=0.015), BMI (p=0.021), dietary energy intake (0.004) and less physical activity level (p=0.083), consistent with higher risk of obesity when compared to negative carriers. Additionally, an interaction with general metabolic condition was found, positive allele A subjects showed higher fasting plasma glucose levels (p=0.036) and tended towards higher triglycerides levels (p=0.093), LDL cholesterol (p=0.084) and lower HDL cholesterol (p=0.082). Therefore, we conclude that risk allele A of FTO SNP rs8050136 is present among young adults from northwestern Mexico and it is a risk factor for obesity not only increasing calorie intake but also influencing BMI, body fat, physical activity levels and increased risk of metabolic disorders.