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Efficacy of Various Vitamin D Correction Strategies in Saudi Adults and Children
Author(s) -
AlDaghri Nasser,
AbdAlrahman Sherif,
AlSaleh Yousef,
Aljohani Naji,
AlAttas Omar,
Alokail Majed
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.638.5
Subject(s) - medicine , vitamin , vitamin d and neurology , pediatrics , population , vitamin d deficiency , physiology , environmental health
Background Vitamin D deficiency is highly prevalent in the Saudi population and there are different strategies. This study aims to evaluate the efficacy of different strategies for vitamin D deficiency correction in Saudi adults and children. Methods A total of 1147 Saudi adults (N=159) and children (N=994) [434 boys (mean age 15.9±2.6 years), 560 girls (14.8±1.6), 59 men (39.9±9.8) and 94 women (42.2±10.6)], whose baseline serum 25(OH)D falls below 50nmol/l, were selected from different secondary school students in Riyadh, Saudi Arabia. They were grouped according to different vitamin D correction schemes: sun‐exposure, vitamin D‐fortified milk consumption, oral vitamin D supplementation (1000IU/day) for 6 months and control (advise). Repeat measurement of serum 25(OH)D was done after 6 months. Results Follow‐up results revealed that the prevalence of vitamin D deficiency significantly decreased after 6 months (23.9% at baseline versus 10.7% after 6 months; p<0.001) in the oral vitamin D supplementation group and this was not observed in other correction strategies. 6‐month oral vitamin D supplementation also showed significant associations between changes in improving total and HDL‐cholesterol in both adults and children. The milk group was the least effective strategy in adults and advise (control) group in children. Conclusion A 6‐month oral vitamin D supplementation was the most effective way to improve lipid profile and vitamin D status in both Saudi children and adults than sunlight exposure and vitamin D fortified dairy products consumption. The latter strategy is the least effective in adults and giving advice is the least effective in children, probably due to poor compliance. Support or Funding Information The study was funded by the Prince Mutaib Chair for Biomarkers of Osteoporosis, Vice Deanship of Research Chairs, King Saud University and Synergy Pharma (Dubai, UAE) for providing the supplements used (VitaD1000).