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Neuroprotective Effect of Spirulina maxima Extract against Trimethyltin‐Induced Neuronal Damage in HT‐22 Cells
Author(s) -
Chei Sungwoo,
Koh EunJeong,
Seo YoungJin,
Choi Jia,
Lee YeonJoo,
Hwang JiHyun,
Song JiHyeon,
Choi SeoYun,
Park MinKi,
Lee BooYong
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.636.17
Subject(s) - neuroprotection , neurotoxicity , spirulina (dietary supplement) , viability assay , chemistry , pharmacology , mtt assay , biochemistry , biology , toxicity , cell , organic chemistry , raw material
Spirulina (Arthrospira) includes various species of primitive unicellular blue‐green algae, most commonly S. platensis and S. maxima. one of the common compounds, Spirulina maxima, which is used as a food additive, is a microalga rich in protein and other essential nutrients. It has been reported that Spirulina maxima has anti‐oxidant and anti‐inflammatory effects. Recently, many reports showed the neurotoxicity effects in central nervous system (CNS). Trimethyltin as a compound used a model of cognitive disorders, induces neurotoxicity in CNS. It causes neuropathological symptoms, cognitive impairments, hyperactivity, aggressive behavior, and seizures. So, we investigated the neuroprotective effects of Spirulina maxima extract in cognitive dysfunction by using TMT‐induced model in HT‐22 cells. The results showed that Spirulina maxima extract increases cell viability with TMT exposure by measuring MTT assay in HT‐22 cells. Also, Spirulina maxima Extract inhibited ROS production by decreasing NOX4 and SOD2 related with oxidative stress. In addition, Spirulina maxima Extract elevated protein levels of p‐CREB and BDNF associated with neuroprotective responses. In this results, Spirulina maxima Extract increases the proteins related with neuroprotective effects against Trimethyltin‐Induced Cognitive Disorders in HT‐22 Cells.