Premium
Anti‐Cancer Properties of the Antimicrobial Peptide CDT on A549 Lung Cancer Cells
Author(s) -
Hendrickson Nathan,
Eitel Anna,
Jujjavarapu Murali,
Guthrie Jeffrey,
Evans Hedeel,
HeylClegg Deborah
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.610.4
Subject(s) - antimicrobial , absorbance , lung cancer , cancer cell , peptide , cancer , a549 cell , chemistry , mtt assay , antimicrobial peptides , cancer research , bacteria , microbiology and biotechnology , cell , biology , biochemistry , medicine , oncology , chromatography , genetics
Antimicrobial peptides, showing therapeutic effects against bacteria and cancer, have positive charges which interact with negatively charged membrane components of these cells. In this study, varying concentrations of cysteine‐deleted tachyplasin (CDT) were examined to determine its anticancer effects. CDT was added to human lung cancer cells and incubated in a 96 well plate for several days. In order to measure the number of live cells remaining after treatment, MTT assay was used to measure absorbance. Preliminary results indicate that CDT reduces absorbance, suggesting that it causes tumor cell death.