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Dietary cranberry alleviated colonic inflammation and altered gut microbiota in mice
Author(s) -
Cai Xiaokun,
Gu Min,
Song Mingyue,
Li Zhengze,
Li Fang,
Goulette Timothy,
You Xiaomeng,
Sela David A.,
Xiao Hang
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.454.7
Subject(s) - akkermansia , akkermansia muciniphila , gut flora , lactobacillus , bifidobacterium , feces , inflammatory bowel disease , medicine , microbiology and biotechnology , biology , gastroenterology , food science , immunology , disease , fermentation
Increased consumption of fruits such as cranberry may decrease the risk of several chronic diseases such as inflammatory bowel disease (IBD). However, the exact mechanism of actions of dietary cranberry is unknown. In this study, we determined the effects of whole cranberry powder on IBD as well as the structure of gut microbiota in a mouse model of IBD induced by dextran sodium sulfate (DSS). Our results showed that dietary cranberry treatment significantly decreased the severity of IBD in DSS‐treated mice, evidenced by that cranberry treatment significantly increased colon length, and decreased disease activity and histologic score of IBD in DSS‐treated mice compared to the positive control group (p < 0.05). Moreover, the colonic levels of pro‐inflammatory cytokines (IL‐1β, IL‐6 and TNF‐α) were significantly reduced by cranberry treatment (p<0.05). Analysis of the relative abundance of fecal microbiota in phylum and genus levels reveled that DSS treatment significantly altered the microbial structure of fecal microbiota in mice, and dietary cranberry treatment partially reversed these alterations. Our results also demonstrated that DSS treatment significantly increased the relative abundance of Akkermansia and Sutterella , and decreased the abundance of Bifidobacterium and Lactobacillus in the mouse feces, which was associated with the development of IBD. Importantly, dietary cranberry treatment inhibited Akkermansia and Sutterella , and promoted Bifidobacterium and Lactobacillus in DSS‐treated mice. Overall, our results for the first time suggested that modification of gut microbiota by dietary whole cranberry might contribute to its inhibitory effects against the development of IBD. Support or Funding Information This study was partially supported by fund from USDA and Cranberry Institute.