Premium
Raspberry intake reduces skeletal muscle lipid accumulation and improves insulin sensitivity in mice fed high fat diet
Author(s) -
Du Min,
Zou Tiande,
Wang Bo,
Liang Xingwei,
Zhu MeiJun
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.44.7
Subject(s) - insulin resistance , medicine , endocrinology , skeletal muscle , insulin receptor , insulin , adipose tissue , inflammation , tumor necrosis factor alpha , triglyceride , chemistry , biology , cholesterol
Polyphenolics promote adipose tissue browning and increase lipid oxidation, but their roles in skeletal muscle intracellular lipid accumulation and insulin resistance is unclear. Raspberry contains rich polyphenolic compounds. Objective To test the protective role of dietary raspberry on lipid accumulation and insulin sensitivity in skeletal muscle of mice fed a high fat diet (HFD). Methods Wild‐type male mice were randomly separated into 4 groups and fed with a control diet (CON) or a high fat diet (HFD, 60% energy as fat mimicking the common high energy, high fat diet in western societies) supplemented with 0 or 5% freeze dried raspberry (RAS) for 12 weeks. Results There was insulin resistance in mice fed with HFD without raspberry, as indicated by increased muscle triglyceride content and attenuated insulin signaling; these adverse changes were ameliorated by raspberry supplementation. In addition, inflammation was detected in the skeletal muscle of HFD mice, as shown by the enhanced expression of tumor necrosis factor α (TNFα), interleukin‐6 (IL‐6) and IL‐1β, as well as the increased phosphorylation of p65, a key mediator of inflammatory nuclear factor (NF)‐κB signaling, which was inhibited due to raspberry consumption. Conclusion Raspberry intake improved insulin resistance and suppressed inflammation in skeletal muscle of mice consuming HFD mimicking the popular western high energy diet. Support or Funding Information Supported by National Processed Raspberry Council