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Raspberries modulate postprandial glycemia and markers of lipid oxidation and inflammation in type 2 diabetes
Author(s) -
Schell Jace,
Betts Nancy,
Basu Arpita
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.431.4
Subject(s) - postprandial , medicine , type 2 diabetes , malondialdehyde , diabetes mellitus , meal , lipid peroxidation , lipid profile , lipid oxidation , endocrinology , antioxidant , oxidative stress , biology , biochemistry
Postprandial dysmetabolism of glucose and lipids contributes to endothelial dysfunction and vascular complications in diabetes. Dietary berries have been previously shown to ameliorate meal‐induced excursions in glucose and lipid profiles in non‐diabetic individuals. Emerging research suggests a role of raspberries in reducing cardio‐metabolic risk profiles, though its effects in type 2 diabetes (T2D) is not known. Thus, we examined the hypothesis that dietary red raspberries will improve postprandial rise in glucose and lipids following a high‐fat fast food style meal challenge in participants with established T2D. Participants (n=25) were randomized to receive a high‐fat breakfast meal with or without raspberries (250g frozen) on two separate days, at least one week apart, and blood draws were conducted at fasting, 1, 2 and 4 hours postprandial time points. In addition, participants received a thrice/week dose of raspberries (250g frozen) for two weeks following which blood samples were collected to examine biomarkers of lipid peroxidation and inflammation. We found raspberry supplementation to significantly reduce hyperglycemia compared to the control group at 2 and 4 hours postprandial (p<0.05). However, we did not observe any changes in lipid profiles and vascular measures at any of the postprandial time points between the raspberry and control groups. At two weeks of follow up period from the acute intervention, raspberry supplementation caused a decrease in serum malondialdehyde and interleukin (IL)‐6 levels supporting the antioxidant and anti‐inflammatory effects in participants with T2D (p<0.05). Thus, dietary raspberries deserve further investigation in the nutritional management of diabetes. Support or Funding Information National Processed Raspberry Council