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Serum Branched Chain and Aromatic Amino Acids Are Associated to Overweight, Obesity and Metabolic Alterations in School‐Aged Children
Author(s) -
OcampoMedina Elvira,
MoranRamos Sofia,
MaciasKauffer Luis,
LopezContreras Blanca E,
VillamilRamirez Hugo,
LeonMimila Paola,
VillarruelVazquez Ricardo,
IbarraGonzalez Isabel,
VelaAmieva Marcela,
CanizalesQuinteros Samuel
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.42.3
Subject(s) - overweight , childhood obesity , medicine , obesity , percentile , insulin resistance , endocrinology , amino acid , body mass index , hypertriglyceridemia , metabolic syndrome , anthropometry , metabolomics , triglyceride , chemistry , biology , bioinformatics , biochemistry , cholesterol , statistics , mathematics
Background Childhood overweight and obesity are risk factors for metabolic alterations that could ultimately lead to pathological states. Metabolomics has emerged as a powerful tool to identify biomarkers for metabolic alterations. Multiple metabolomics studies have associated childhood obesity to serum amino acids and acylcarnitines, particularly to an increase in branched chain amino acids (BCAA). Despite these findings, so far there are no studies evaluating the serum amino acid profile in Mexican children. Therefore we aimed to identify amino acids associated to overweight, obesity and its metabolic alterations in Mexican school‐aged children. Methodology Anthropometric and biochemical measurements were conducted in 845 children (6–12 years old) from a cross‐sectional study in Mexico City. Targeted metabolomics was performed by mass spectrometry. Children were classified according to their BMI percentile (BMIp) as low weight (LW; BMIp<5 th ), normal weight (NW; 5 th