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Evolution and the proteome: Insights into protein function from deeply conserved gene modules
Author(s) -
Marcotte Edward
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.259.2
Subject(s) - proteome , biology , computational biology , gene , function (biology) , evolutionary biology , conserved sequence , phenotype , genetics , phylogenetics , yeast , genome , peptide sequence
I'll describe our attempts to test the extent to which deeply homologous genes and pathways are predictive across distant eukaryotic species, including our search for new models of human disease among phenotypes of distant organisms, our attempts to systematically humanize yeast cells, and our program to apply high‐throughput protein mass spectrometry in order to measure conserved physical interactions among the thousands of proteins shared across the eukaryotic tree of life. Studies such as these reveal the evolutionary basis for traits and diseases, help annotate the expressed proteomes of major eukaryotic lineages, and reveal the evolutionary conservation, divergence, and rewiring of protein complexes across eukaryotic proteomes.