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Bacterial metabolism and antibiotic efficacy
Author(s) -
Collins James J
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.257.1
Subject(s) - antibiotics , bacteria , microbial metabolism , microbiology and biotechnology , biology , medicine , genetics
In this talk, we will highlight recent work in network biology aimed at elucidating the mechanisms of action of antibacterials and bacterial responses to antibiotic treatment. Of note, we highlight recent work showing that antibiotics perturb the metabolic state of bacteria and that the metabolic state of bacteria impacts antibiotic We discuss how the insights arising from these studies can be harnessed to create more effective antibiotics and innovative antibacterial therapies to treat resistant and persistent infections.