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Patterning coronary artery development
Author(s) -
RedHorse Kristy
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.250.2
Subject(s) - process (computing) , coronary artery disease , progenitor cell , biology , stem cell , medicine , computer science , microbiology and biotechnology , operating system
An important goal of developmental biology is to understand how millions of cells unite to produce a complex organ. For this process to be successful, the cells must take on proper fates at the appropriate times, in the correct proportions, and organize themselves so that the organ functions effectively. We are using the cardiovascular system as a model to understand the rules of these developmental events. Our laboratory is specifically focused on how cardiovascular progenitor cells behave in three dimensions and at the single cell level with inputs from physical forces. This allows us to study coronary development at high resolution to gain new information on how the cardiovascular system is assembled during embryogenesis and how developmental programs are reignited during disease. Support or Funding Information This research is supported by NHLBI of the National Institutes of Health under award number R01 HL128503.