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Hematopoietic stem cell induction and development
Author(s) -
Zovein Ann Capela
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.250.1
Subject(s) - microbiology and biotechnology , haematopoiesis , stem cell , biology , hematopoietic stem cell , cell fate determination , endothelial stem cell , regenerative medicine , immunology , transcription factor , genetics , gene , in vitro
Hematopoietic stem cells (HSC) are generated during embryogenesis from specialized endothelium, termed hemogenic endothelium, in a transient process. We present our recent work dissecting the signaling pathways that regulate hematopoietic versus endothelial fate during hematopoietic stem cell emergence. We demonstrate cell intrinsic and extrinsic signaling are part of the hemogenic program. Arterial fate specifiers are required to be down regulated in hemogenic endothelium, with acquisition of hematopoietic fate determinants in emerging hematopoietic cells, which also exhibit changes in cell cycle dynamics and acquisition of inflammatory mediators. In addition, we explore a possible role of the supporting mesenchyme. Support or Funding Information The work was supported by the NIH 1DP2HL117743‐01 Award, and the California Institute for Regenerative Medicine New Faculty award RN3‐06479.