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Role of H3K36 methylation in cell cycle control and nutrient stress response
Author(s) -
Strahl Brian
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.113.1
Subject(s) - chromatin , methyltransferase , microbiology and biotechnology , biology , cell cycle , transcription (linguistics) , transcription factor , methylation , transcriptional regulation , cell , genetics , gene , linguistics , philosophy
H3K36 methylation (H3K36me) is a co‐transcriptional modification critical for the maintenance of chromatin structure and the fidelity of transcription. However, the extent to which the control of transcriptional fidelity by Set2/H3K36me broadly impacts cellular functions such as cell cycle control and stress response is not known. In my presentation, I will describe our recent work into the role of the H3K36 methyltransferase Set2. Our studies show that Set2 is not only cell cycle regulated, but also required for proper cell cycle progression and nutrient stress response – findings that appear to be conserved in humans. We propose that the ability of Set2/H3K36me to reinforce chromatin structure and prevent pervasive anti‐sense/cryptic transcription is required for the proper regulation of highly timed transcription programs such as those found in the cell cycle and nutrient signaling.