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Korean probiotic kimchi prevented Helicobacter pylori ‐associated gastric cancer in mice and human
Author(s) -
Han YoungMin,
Park JongMin,
Lee Dongyun,
Oh Ji Young,
Hahm Ki Baik
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1067.1
Subject(s) - helicobacter pylori , atrophic gastritis , medicine , cancer , gastroenterology , carcinogenesis , probiotic , gastritis , stomach , inflammation , cancer prevention , immunology , biology , bacteria , genetics
As dietary, non‐microbial intervention whether Korean probiotic kimchi can prevent Helicobacter pylori ‐induced atrophic gastritis as well as gastric cancer, we have tried either in vitro / in vivo experimental model of chronic H. pylori ‐initiated, high salt diet‐promoted, gastric tumorigenesis in mice model and clinical trial to explore the real impact of kimchi administration on to the changes of fecal microbiota. H. pylori ‐infected C57BL/6 mice were administered with cancer preventive kimchi (cpKimchi) mixed in drinking water up to 36 weeks and cancer preventive actions of anti‐inflammation and anti‐mutagenesis were compared between standard recipe kimchi (sKimchi) and special recipe cpKimchi. As results, the erythematous and nodular changes, mucosal ulcerative and erosive lesions in the stomach were noted at 24th weeks, but cpKimchi administration significantly ameliorated these gastric pathologies and after 36th weeks, scattered nodular masses, some ulcers, and thin nodular gastric mucosa were noted in H. pylori ‐infected mice, whereas these gross lesions were significantly attenuated in cpKimchi group. Significant expressions of COX‐2 and IL‐6, activated NF‐κB and STAT3, increased apoptosis, and marked oxidative stresses were noted in H. pylori ‐infected group relevant to tumorigenesis, but these were all significantly attenuated in cpKimchi group. cpKimchi administration afforded significant changes in fecal microbiota, implicated in cancer preventive actions. In conclusion, daily dietary intake of cpKimchi can be an effective way either to rejuvenate H. pylori ‐atrophic gastritis or to prevent tumorigenesis supported with the concerted actions of anti‐oxidative, anti‐inflammatory, and anti‐mutagenic mechanisms.