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Anti‐inflammatory and Neuroprotective Effects of Co‐ultraPEALut in a Mouse Model of Vascular Dementia
Author(s) -
Siracusa Rosalba,
Cordaro Marika,
Impellizzeri Daniela,
Crupi Rosalia,
Esposito Emanuela,
Cuzzocrea Salvatore
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1061.8
Subject(s) - neuroprotection , vascular dementia , dementia , oxidative stress , medicine , inflammation , pharmacology , population , ischemia , disease , environmental health
Vascular dementia, the second most common cause of cognitive impairment in the population, is a disease with a progressive course of cognitive impairments that results from reduction in regional cerebral blood flow and involves oxidative stress and inflammation. Co‐ultraPEALut is a new compound with beneficial effects, which include anti‐inflammatory and anti‐oxidant properties. Recently, co‐ultraPEALut has been shown to exhibit neuroprotective effects in models of Parkinson's disease, cerebral ischemia and Alzheimer's disease. However, its effects on vascular dementia remain unclear. Therefore, the present study examined the neuroprotective potential of co‐ultraPEALut containing N‐Palmitoylethanolamine (PEA) and the anti‐oxidant flavonoid luteolin (Lut) (10:1 by mass) in a mice model of vascular dementia using bilateral carotid arteries occlusion. At 24 hours after model induction, mice were orally administered 1 mg/kg co‐ultraPEALut daily and for 15 days. On the 15th days, brain tissues were processed for histological, immunohistochemical, Western blot and immunofluorescent analysis. Our results showed that co‐ultraPEALut improved learning, memory ability, locomotor activity and the reciprocal social interaction. Furthermore, mice subjected to vascular dementia and treated with co‐ultraPEALut showed reduced expression of pro‐inflammatory, pro‐apoptotic markers and of oxidative stress. These results confirmed that the neuroprotective effects of co‐ultraPEALut on vascular dementia were associated with its anti‐inflammatory and anti‐oxidant properties.