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Assessment of Hydration State by Combining Urine Color and Void Number
Author(s) -
Adams J.D.,
Johnson Evan C,
Jansen Lisa T,
Mauromoustakos Andy T,
Perrier Eric,
Kavouras Stavros A
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1027.12
Subject(s) - urine , receiver operating characteristic , urine osmolality , area under the curve , area under curve , urology , void (composites) , medicine , endocrinology , materials science , pharmacokinetics , composite material
PURPOSE To evaluate the diagnostic ability of two combined practical markers for elevated urine osmolality in free‐living adults. METHODS One hundred and one healthy adults (females N=52, 1.64±0.06 m, 72.0±16.6 kg, 26.9±6.1 kg/m2; males N=49, 1.77±0.07 m, 81.5±16.0 kg, 26.0±4.7 kg/m2) collected urine for 24 h on two occasions day 1 (D1) and day 2 (D2), separated by 1 week. Urine was analyzed for urine osmolality (UOsm), color (UC), while the number of voids (Void) was also recorded. Receiver Operating Characteristic (ROC) analysis was performed for UC, Void, and combination of UC and Void, to determine markers' diagnostic ability for detecting high urine osmolality (UOsm >500 mmol·kg−1). RESULTS For the first and second day, UOsm was 415±216 & 457±225 mmol·kg−1, UC was 2±1 & 2±1, and Void number was 8±3 & 8±3. ROC analysis results for UC for UOsm>500 mmol·kg−1 both D1 and D2 had good overall classification ability (area under the curve, AUC 81–85%), with good sensitivity (77–81% and good specificity (76–80%). Threshold analysis revealed a UC > 3 for both D1 and D2. ROC analysis results for Void for D1 and D2 had good overall classification ability (AUC both 72%), with good sensitivity (78–80%), but moderate specificity (67–74%). Threshold analysis revealed a void number > 8 for D1 and > 7 D2. Based on the ROC analysis, combining both UC and Void number displayed good overall classification ability for D1 and D2 (AUC 84–86%) with moderate sensitivity (69–78%), and good specificity (89–90%). CONCLUSION Both urine color alone and the combination of urine color with void number can be used as a valid and simple diagnostic measure to detect elevated urine osmolality. Support or Funding Information The study was supported by a grant by Danone Research