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Chronic Intermittent Hypoxia Promotes Multiple Myeloma Development in Black/6 Mice
Author(s) -
Kowkuntla Sandeep,
Xu Hongwei,
Tomasson Michael H,
Bates Melissa
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1024.6
Subject(s) - medicine , bone marrow , intermittent hypoxia , hypoxia (environmental) , disease , multiple myeloma , pathology , endocrinology , surgery , obstructive sleep apnea , chemistry , organic chemistry , oxygen
Multiple myeloma (MM) is an incurable malignancy of bone marrow plasma B cells and is associated with obesity. Decreased levels of the lipokine adiponectin are associated with disease risk in obese patients with MM, but the mechanisms by which obesity contributes to MM remain unclear. Obesity is also associated with sleep apnea and chronic intermittent hypoxia (CIH) and MM cells develop aggressive features when exposed to hypoxia, so we hypothesized that CIH would facilitate disease progression in a mouse model of MM. 5TGM1 cells are a murine MM cell line derived from KaLwRij strain that fail to engraft efficiently in Black6 strain mice. We injected 5TGM1 MM cells into two cohorts of Black/6 mice, one control and one exposed to intermittent hypoxia for one week prior to injection and another three weeks after injection for a total of four weeks. None of the control mice developed disease after two months, but two of five (40%) CIH mice developed MM disease characterized by hind limb paralysis and bone marrow infiltration with GFP‐positive 5TGM1 cells. These results suggest that CIH may contribute to the development of MM. Further studies are warranted. Support or Funding Information University of Iowa Start‐Up Fund