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Resistance training with short interval does not induce skeletal muscle hypertrophy in rats
Author(s) -
Takegaki Junya,
Kotani Takaya,
Ogasawara Riki,
Tsutaki Arata,
Nakazato Koichi,
Ishii Naokata
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1021.15
Subject(s) - isometric exercise , skeletal muscle , muscle hypertrophy , medicine , resistance training , gastrocnemius muscle , interval training , stimulation , christian ministry , endocrinology , physical therapy , philosophy , theology
Resistance training is an effective tool for increasing the skeletal muscle mass and strength. The resistance training effect is recognized to depend on the training frequency, together with intensity, volume, etc. However, the detailed response according to the training frequency remains unclear. Purpose To see changes in skeletal muscle hypertrophy and relating factors after equal sessions of resistance exercise by changing the training interval. Methods Male Sprague‐Dawley rats were randomly assigned into three groups: resistance‐trained with 18 bouts at interval of 72h (72H), 24h (24H), and 8h (8H). The resistance exercise consisted of 50 repetitions of maximal isometric contraction of the gastrocnemius muscle. The right gastrocnemius muscle was used as trained muscle, and the left was used as internal control. The muscle contraction was induced by transcutaneous electrical stimulation under anesthesia. Muscle samples were collected 48h after the final exercise session, and kept frozen until analysis. Results Gastrocnemius wet weight was increased in 72H and 24H, but not in 8H. Mitochondria content was increased in 72H and 24H, but not in 8H. The protein ubiquitination was observed in all groups, and the ubiquitination was increased with shortening of training interval. Conclusion The present results suggest that resistance training with 8h interval does not cause skeletal muscle hypertrophy, and the hostile environment for anti‐catabolism is one of the possible causes for this. Support or Funding Information This work was supported by grants‐in‐aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (15H03078 to N.I.).