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The Effect of Exercise Pattern on Insulin Responses in Healthy, Young Males
Author(s) -
Castleberry Todd,
Ramirez Joel,
Deemer Sarah E,
Irvine Christopher,
Rouwtt De'Andrea,
Oldham Michael,
BenEzra Vic
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1020.7
Subject(s) - insulin , medicine , morning , endocrinology , analysis of variance , treadmill , repeated measures design , post hoc analysis , plasma glucose , physical exercise , statistics , mathematics
BACKGROUND It is often reported that a single bout of exercise lowers insulin responses 12–24 hours post exercise. It is not known if alternate or consecutive days of exercise have an additive effect on insulin responses. Our hypothesis is that both alternate and consecutive days of exercise will improve insulin responses/glucose control more than a single bout of exercise. PURPOSE The purpose of this study was to examine the effect of exercise pattern on post‐exercise insulin and glucose responses to a glucose challenge. METHODS Eleven healthy adult male participants (n=11, mean ± SD, 28.6 ± 7.9 yrs; BMI: 25.7 ± 2.8 kg/m 2 , VO 2max ; 38.7 ± 4.7 ml/kg/min; fasting plasma glucose: 4.85 mmol/l; fasting plasma insulin: 8.4 μU/ml) completed three submaximal exercise trials of walking on a treadmill for 60 minutes at ~70% of VO 2max . The trials consisted of: 3 consecutive exercise days (3CON), 3 alternate exercise days (3ALT), a single bout of exercise (SB), and a no exercise control (R). In the morning, 12–14 hours after the last bout of exercise or R, participants completed a 75g oral glucose tolerance test and blood was collected at 0, 30, 60, 90, 120, and 150 minutes for the measurement of glucose, insulin, and C‐peptide. Glucose was analyzed using enzyme electrode technology (YSI 2900) and insulin and C‐peptide were measured via ELISA. A one‐way repeated measures ANOVA with a Bonferroni post hoc was used for statistical analysis. Diet logs were kept throughout each trial to ensure consistency for all participants. RESULTS Calculated integrated area under the curve ( i AUC) for glucose and C‐peptide was not different between the 4 trials. Insulin i AUC was significantly decreased 33.9% for 3CON compared to R (p=0.006). Insulin i AUC decreased for SB (8.4%) and 3ALT (24.1%) compared to R, however these values did not reach statistical significance. CONCLUSION Three consecutive days of walking at ~70% VO 2max improved insulin response to a 75g glucose load compared to no exercise. Interestingly, a single bout of exercise and three alternate days of exercise did not significantly improve insulin responses compared to no exercise. It is possible, that for healthy, young males, the response to a single bout of exercise, or exercise bouts separated by more than 24 hours may not be enough stimulus to improve insulin responses.