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Sex‐Related Differences in Reactivity of Cerebral Arterioles During Moderate Exercise Training
Author(s) -
Arrick Denise M,
Li Chun,
Mayhan William
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1020.3
Subject(s) - sed , enos , vasodilation , medicine , endocrinology , nitric oxide , nitric oxide synthase
Background The goals of our study were to determine the influence of sex on reactivity of cerebral arterioles and whether moderate exercise training (MExT) could influence sex‐related differences in reactivity of cerebral arterioles. Methods Responses of cerebral arterioles were measured in Sedentary (Sed) and MExT adult male and female Sprague‐Dawley rats to eNOS‐dependent (ADP); nNOS‐dependent (NMDA) and NOS‐independent (nitroglycerin) agonists before and following L‐NMMA. In addition, protein expression for eNOS and nNOS was determined. Results We found that NOS‐dependent vasodilation was enhanced in Sed and MExT female rats compared to their male counterparts. L‐NMMA produced a greater decrease in baseline diameter of arterioles in females compared to males, and produced less inhibition of NOS‐dependent vasodilation in females. Expression of eNOS protein was significantly increased in Sed female when compared to Sed male rats, nNOS protein was similar in Sed males and females, but increased in MExT females. Conclusions These findings indicate that while NOS‐dependent vascular reactivity is increased in females, MExT does not alter vasodilation in males or females. These studies provide insights into the influence of sex and MExT on the cerebral microcirculation and may have implications regarding mechanisms that protect the brain in females compared to males during disease states.