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Physical Activity Following A 14 Day Recovery Period Was Greater In Aging CBA/J Mice After A Significant Ankle Sprain
Author(s) -
Turner Michael J.,
Wikstrom Erik A.,
HubbardTurner Tricia
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1020.23
Subject(s) - medicine , analysis of variance , ankle , quartile , physical activity , repeated measures design , sham surgery , surgery , physical therapy , confidence interval , pathology , statistics , alternative medicine , mathematics
A significant lateral ankle sprain results in a decrease in lifelong physical activity, with increased likelihood for chronic disease development. To investigate the impact of different rest periods on lifelong activity, we transected the CFL and ATFL of the right hindlimb in 18 male CBA/J mice at seven weeks old. Each mouse was placed in separate cages and randomized into three groups of six mice and received a running wheel three days (3D), seven days (7D) or 14 days (14D) post‐surgery. Physical activity was measured daily from eight weeks until 52 weeks of age (72% of lifespan). Daily duration, distance and running speed were analyzed by ANOVA (Group × Time) with repeated measures (p<0.05) at 15‐week periods to approximate the first three quartiles of lifespan. From weeks three to 15 post‐surgery, duration, distance, and running speed were not different between groups, but all activity variables increased with time (p<0.05). From weeks 16 to 30 post‐surgery, distance (p=0.041) and running speed (p=0.010) were greater in the 14D group compared to 3D and 7D, while duration was not different among the groups (p=0.185). There were no differences with time from 16 to 30 weeks (p<0.05). From weeks 31 to 45 post‐surgery, duration (p=0.020), distance (p=0.009) and running speed (p=0.007) were greater in the 14D group compared to 3D and 7D. No differences were found with time from 31 to 45 weeks (p>0.05). Our findings suggest the longer rest period of 14 days following a lateral ankle sprain can significantly increase activity levels (duration, distance and running speed) throughout the second and third quartile of life. Support or Funding Information Supported by UNC Charlotte Faculty Research Grants (Turner, Wikstrom, and Hubbard‐Turner).